PainOnline.com

Here we attempt to make things a little simpler, so you can follow the literature on ion channels and pain drugs. This is the beginning of a ssries which will appear here on this topic. The field changes pretty rapidly so some of it will be controversial by the time it appears. Isn’t it great the scientists are moving along so rapidly! Movement is what you see before a cure is found. Open the gate, and let us out, or as these articles will point out, close the gate, and stop the pain.

Calcium Channels and Pain, Part I

We are greatly indebted to Joseph McGivern, and his associate, Stefan McDonough, from Amgen, for providing us the following information. Although in truth, some of it quotes or repeats rather closely what he has published, it is too cumbersome to fill sentences with quote marks, so we advise you to read the article referenced by him, where you will see that this is largely from it. Because most of this is heavy reading, we have decided to post it in parts, to give time for certain concepts to settle, before moving on. Various authors may submit other articles in the meantime, so do not be confused if articles on other topics appear between consecutive parts. There are always opinions of our own interspersed, for better or for worse, but the bulk of this information comes from McGivern and McDonough from Jan 2005, Current Drug Targets,