We are better prepared to answer questions on tensor analysis, quark arrangement, and dark matter. But the weary and discouraged people who write do not send us questions on that. They want to know WHY they must suffer. Maxwell was correct that “suffering is deep doctrine”. Couldn’t you make your questions a little easier?
A question which we have dodged, because we can
November 1st, 2006 at 9:01 am #jrueus
Perhaps NK1/Substance P antagonist, or heat shock protein inhibitors(below) that might provide neuroprotection in a constantly reperfusion injury neuroimmune environment (similar to antioxidants protecting against free radicals)
The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells.
* Koike T,
* Uno S,
* Ishizawa M,
* Takahashi H,
* Ikeda K,
* Yokota S,
* Makishima M.
Department of Biochemistry, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan; Department of Applied Biological Science, Nihon University College of Bioresource Sciences, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan.
The nervous system is highly sensitive to various environmental stresses, such as ischemia. Stress response mechanisms that result in neuroprotection, including the induction of heat shock proteins (HSP), are not well understood. We examined the effect of KNK437, a compound that inhibits the synthesis of inducible heat shock proteins, on neuronal differentiation in rat pheochromocytoma PC12 cells. KNK437 decreased the expression of HSP70, and induced the neurite outgrowth of PC12 cells in the absence of stress stimulation, although with lower efficacy than nerve growth factor (NGF). Neurite outgrowth stimulated by KNK437 and NGF was blocked by inhibitors of ERK mitogen-activated protein (MAP) kinase, p38 MAP kinase, and glycogen synthase kinase 3beta signaling pathways. NGF, and not KNK437, induced acetylcholine esterase (AChE) activity, a functional differentiation marker, indicating that KNK437 utilizes a mechanism distinct from that of NGF. KNK437 enhanced the activity of low dose NGF treatment on neurite outgrowth induction and ERK phosphorylation in PC12 cells, a finding that identifies KNK437 as a possible nerve regeneration agent. This compound may be a useful tool for the investigation of neuronal differentiation and neuroprotection against environmental stress.
PMID: 17055158 [PubMed - as supplied by publisher]
wikipedia:heat shock protein
(for reference background on heat shock proteins)