Here are the results of the first really double blind study on pregabalin in central pain. The results are encouraging.
For nearly ten years, there has been evidence that stimulation of the motor cortex can help central pain. TCDS is “trans-cranial direct current stimulation”.
Many years ago, there was a popular song which talked about how love might be defined. The tune ducked the whole thing and said “Happiness is just a guy named Joe”. Cutting everything to the absolute core is known as “applying Occam’s razor”.
This author is part Cherokee, so that conflict of interest is disclosed at the outset.
A very important concept is that injury spreads. This happens at a cellular level due to release of chemicals from injured cells into surrounding cells. It is surprising how toxic materials in the body become once they are out of place. Blood, for example, is very toxic outside the blood vessel. Blood clots to the lung do not kill people, but the spreading of chemicals released FROM the clot does kill people. Now we are beginning to understand how spreading injury operates in injured pain nerves. Neighbor neurons are reprogrammed to make exciters, as if warning the brain of pain is the main duty. When glutamate leaks out in cell injury, havoc occurs.
We have praised Clifford Woolf before and now he and his colleagues have completed a blockbuster study on a model of peripheral nerve injury and inflammatory pain, footed on an enzyme heretofore only known to be of relevance in a type of dystonia.
Free agency is what makes us real individuals rather than robots. Being human is footed on it. It is just so hard to get through our heads that free agency is the biggest thing going.
When Windows operating system starts to run funny, system administrators refer to it as “Windows Rot”. It is not unusual for businesses to routinely reinstall Windows programs every six months to avoid windows rot. Somehow, somewhere, the programming drops something. We are learning that genetic reprogramming is also a bad thing.
How often have we heard it. “Physical pain can never compare to emotional pain.” If we rephrase to say “Emotional pain can never compare to CHRONIC physical pain”, it is a different matter.
Just as there is spontaneous and evoked burning dysesthesia, there is spontaneous and evoked cramp in the muscles in fully elaborated Central Pain.