In 1999, the Miami Spine Project reported the first experience with producing GABA with cell lines injected into the spinal fluid. Now, there is more good news. We have been waiting for the first big break. Ziconotide seemed to be it, but has side effects in many at effective doses. Now comes hope from another direction. Thank heaven for the cellular biologists.
Pain can create a focus like nothing else. However, if one must live with pain perpetually, as in central pain, there must be a constant effort to look outward, even as we take care not to deplete the energy necessary to endure.
Pain research continues to be controversial, partly because the public does not realize opiates generally don’t help central pain (except by sedation); but also because the receptors which produce pain in the cell membrane are responsive to a variety of drugs, some of them illegal, (such as opioids and cannabioids)
The recent revelation that William Rehnquist had a pain problem and drug use to go along with it has stirred psychiatrists to debate the “ethics” of prescribing pain meds. We do not usually receive many visitors here in this corner of the pain zoo, so we are happy to see anyone, especially a psychiatrist, look our way. Welcome, where have you been?
The approaching episode of House on Tuesday (now past) should provide more reflection on whether the public can view pain accurately.
We are not alone in nerve injury pain. We merely lack the visual markers “enjoyed” by some others. We aren’t trying to steal anyone’s thunder, but a little truth never hurt anyone.